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A New Genetic Marker of Human IgG3 Immunoglobulins
Author(s) -
Loghem Erna van,
Grobbelaar B. G.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb04796.x
Subject(s) - antiserum , serology , biology , antibody , antigen , genetic marker , genetics , epitope , microbiology and biotechnology , gene
. A new antigenic determinant was found which is present on proteins of the main IgG3 allotypes, Gm(g) and Gm(b), but absent from IgG3 proteins carrying Gm(s). It was shown to be a genetical marker in family studies. The antiserum detecting this specificity is similar to antisera of ‘long specificity’, which term is used in HL‐A serology. The antigenic determinant offers a link for the generation sequence of Gm allotypes during evolution.