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A New Antibody, anti‐ILe bH , Specific for a Determinant Formed by the Combined Action of the I, Le, Se and H Gene Products 1
Author(s) -
Tegoli J.,
Cortez Myrna,
Jensen Leila,
Marsh W. L.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb04795.x
Subject(s) - antibody , chemistry , antigen , microbiology and biotechnology , red cell , stereochemistry , biochemistry , immunology , biology , medicine
. A new antibody has been found that agglutinates only group O or A 2 , I, Le(a‐b +) red cells. The reacting antigen appears to be a product of interaction between the I, Le, Se and H genes and the antibody has been named anti‐ILe bH . The antibody can be inhibited by saliva containing I, H, and Le b substances, but is not inhibited by serum from the same people. Transformation experiments, aimed at changing ILe bH ‐negative red cells into ILe bH ‐positive, were unsuccessful and it was concluded that the reacting antigen is of red cell origin and does not arise by passive adsorption of group substance from the plasma.