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An Enhancing Effect of Albumin on the Determination of Cold Hemagglutinins 1
Author(s) -
Haynes C.R.,
Chaplin H.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb01799.x
Subject(s) - agglutination (biology) , cold agglutinin , titer , albumin , bovine serum albumin , chemistry , serum albumin , human albumin , saline , hypogammaglobulinemia , hemagglutination , medicine , immunology , chromatography , biochemistry , antibody
. Serum from a patient with hypogammaglobulinemia was found to have a cold agglutinin titer of 128 when diluted in saline and 131,000 when diluted in 22% bovine serum albumin. Human Serum albumin and a non‐protein‐containing commercial agglutination potentiator had similar enhancing properties. A degree of albumin enhancement of cold agglutination was observed in approximately 25% of normal and patient sera examined. The mechanism of enhancement and the possible clinical significance of the phenomenon are not yet known.