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Observations of the Number of Available c, D, and E Antigen Sites on Red Cells
Author(s) -
HUGHESJONES N. C.,
GARDNER BRIGITTE,
LINCOLN P. J.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb00578.x
Subject(s) - antigen , microbiology and biotechnology , antibody , phenotype , chemistry , biology , immunology , biochemistry , gene
. The number of available antigen sites within the Rh system were estimated using trace‐labelled antibodies. The results were as follows, given as the number of sites per red cell: c‐antigen: on cc cells, 70,000–85,000: on Cc, 37,000–53,000; D sites on cells of phenotype ‐D‐: 110,000–202,000; E‐antigen sites showed considerable heterogeneity depending on phenotype as well as source of anti‐E, and estimates varied between 450 and 25,600; e‐antigen: on eE cells, 13,400 and 14,500: on ee cells, 18,200 and 24,400. The average equilibrium constants of the antibodies were: anti‐E, 4 × 10 8 1/mol; anti‐e, 2.5 × 10 8 1/mol; anti‐c, 3.2 × 10 7 and 5.6 × 10 7 1/mol.