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Immunogenetic Studies of Rhesus Monkeys 1
Author(s) -
Duggleby C. R.,
Blystad C.,
Stone W.H.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb00545.x
Subject(s) - phenotype , allele , biology , blood grouping , genotype , mendelian inheritance , genetics , blood typing , typing , rh blood group system , abo blood group system , immunology , gene , antibody
. We have produced 7 typing reagents (agglutinins) reactive with the erythrocytes of rhesus monkeys ( Macaca mulatta ). Each detects a unit antigenetic factor controlled by a Mendelian dominant autosomal gene. The blood factors fall into 5 clearly defined independent blood group systems, named H, I, J, K and L. The H system consists of 2 isoimmune reagents that react best in an anti‐globulin test. There are 3 phenotypes and 3 genotypes, but no H‐negative phenotype in this system. The I system consists of 2 isoimmune reagents also, but there is a ‘silent allele’ producing a non‐reactive phenotype, consequently the I system has only 4 distinguishable phenotypes among its 6 genotypes. The remaining 3 reagents (J‐1, K‐1, and L‐1) each detect a single factor; each system is defined as the presence or absence of this factor. Statistic and genetic tests on over 300 families at the Wisconsin Regional Primate Research Center indicate that each system is genetically independent. Using these 7 reagents plus the 5 reagents of which the G‐system is comprised, as previously described [2], it is now theoretically possible to distinguish almost 5,000 blood types in the rhesus monkey.