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The Definition of Two I Antigen Components 1
Author(s) -
Marsh W. L.,
Nichols Margaret E.,
Reid Marion E.
Publication year - 1971
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1971.tb00432.x
Subject(s) - antigen , immunology , cord blood , fetus , biology , isoantigens , red cell , leukemia , medicine , pregnancy , genetics
. The I blood group antigen has two main components named I Fetal (I F ) and I Developed (I d ). The I F component is present on all human red cells including those of i cord and i adult persons, and also on Rhesus monkey red cells. The I D component develops slowly on the red cells before birth and to a greater extent in the 18 months after birth. Inhibition studies with human milk show that strongly‐inhibitable anti‐I sera are of the anti‐I D variety, but only a minority of such sera are inhibitable. Comparative studies on the red cells of 12 newborn infants suggest that the same sequence of I antigen development occurs in them all, but different infants vary in the amount of I development that they have achieved at the time of birth. I antigen variants affect mainly the I D component, and it is this part of the antigen that may be weakened on the red cells of people with leukemia.