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Plasma Protein Fraction (Human)
Author(s) -
Hink J. H.,
Pappenhagen .A. R.,
Lundblad J.,
Johnson F. F.
Publication year - 1970
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1970.tb02185.x
Subject(s) - albumin , blood proteins , globulin , chemistry , zoology , lability , fraction (chemistry) , chromatography , medicine , biochemistry , biology
. Plasma Protein Fraction, USP (PPF) has largely replaced preparations of pooled plasma as a plasma expander. Three commercial lots of PPF (Plasmanate ®‐Cutter) prepared in 1959 were subjected to a planned stability study extending over a nine year period with the following findings: 1. Motion lability was not adversely affected by storage for periods up to 7 years at temperatures of 25° or below. 2. With extended time, there was a small gradual decrease in the albumin component and a corresponding increase in a component with an electrophoretic mobility of alpha‐globulin but with a sedimentation rate equivalent to that of albumin; this rate of change was greatly accelerated at 40°. 3. Viscosity increased at a rate of approximately 0.3% per year at 5° and 25°; at 40° viscosity increased sharply with extended time. 4. Turbidity was little affected by time and temperature except for periods in excess of 2 years at 40°. 5. No antigenic changes were detectable after 2 years at 40° or 8 years at 25°. 6. Clinical studies in normal volunteers with PPF stored 9 years at 25°, and in ill patients with PPF stored 2 years at 40° and 9 years at 25° showed no adverse reactions. It is concluded that Plasma Protein Fraction can be safely used after storage for 5 years at temperatures not exceeding 30°.