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Positive Direct Coombs Tests with Anti‐IgA Antiserum
Author(s) -
MACKENZIE M. R.
Publication year - 1970
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1970.tb01776.x
Subject(s) - antiserum , antibody , coombs test , antigen , immunoglobulin a , immunology , immunoglobulin g , medicine , chemistry
. Six patients with hemolytic anemia were found to have positive direct antiglobulin tests with antisera to IgA, in addition to positive reactions with anti‐IgG, ‐IgM or C3 antisera. Absorption studies suggest that IgA exists as a complex with other immunoglobulins. IgA found on such erythrocytes may be a true auto‐antibody but may represent absorption of this immunoglobulin by antigen‐antibody complexes.