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Red Cell Sp 1 Antigen Change Associated with in vivo Poly‐Agglutinability 1
Author(s) -
Beck M. L.,
Marsh W. L.
Publication year - 1970
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1970.tb01499.x
Subject(s) - center (category theory) , medicine , gerontology , chemistry , crystallography
Spl is tlir iiiirrie given hy MARSH and J E N K I N S [a] to the highfrcqiicricy rctl cell antigen rrcognizetl l q some cold auto-agglutinins. One of the hclrological fcnt,urcbs (listingiiishiiig anti-Sp, from anti-I is the cliff'errnce in reactivity after treat.nirrit of the red cells with the enzymes, Gcin anid pliairi. Anti-I is enhanced by using enzymetreated retl cdls but the Sf), rrtl cell receptor is inactivated. MARSH arid NICHOLS [3] subsequeritly reportcd in uitro experiments showing that some hactcrial filtrates containing proteolytic enzymes caused activation of the red c.c.11 T-antigen hut a t the same time caused denaturation of Spl. All of these antigen changes are believed to result from bacterial enzyme activity. This report presents a case of i n vivo poly-agglutinability which was accompanied hy loss of the red-cell Spl antigen. The patient, a woman aged 47 years, had a pelvic ahcess. Clostri&urn p r f r i n g e n s ant1 Clostridiurn but.yricurn were isolated from the woiintl. Her retl cells were ply-agglutinable (T-active) and were strongly agglutinated by group AB serum and by a saline extract of Arachis h.ypogea [l]. We were unable t o establish the Sp, status of the patient's retl cells before they became ply-agglutinable.