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The Influence of Modifying the Surface Properties of Sheep Red Cells Upon Hemolytic Antibody Production in Mice 1
Author(s) -
WILKINS D. J.,
BLIZNAKOV E. G.
Publication year - 1970
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1970.tb01442.x
Subject(s) - microelectrophoresis , antibody , gelatin , antigen , immunology , chemistry , red blood cell , biology , microbiology and biotechnology , electrophoresis , biochemistry
Summary. The studies reported here indicate that the sheep red blood cell surface can be modified with poly‐L‐lysyl gelatin, and such changes can be monitored by the technique of microelectrophoresis. When these cells are injected into mice, enhanced levels of hemolytic antibody are obtained over control unmodified cells for the primary, early, and late secondary responses. Although the experiments were designed primarily to demonstrate the phenomena, rather then to determine the mechanism, it seems unlikely that the enhancement is due to physical modification of the antigen.