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Automatically Controlled Continuous Recovery of Plasma Protein Fractions for Clinical Use: A Preliminary Report
Author(s) -
Watt J. G.
Publication year - 1970
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1970.tb01428.x
Subject(s) - fractionation , continuous flow , plasma , human plasma , chromatography , protein precipitation , volumetric flow rate , chemistry , process engineering , environmental science , computer science , biochemical engineering , mechanics , engineering , physics , quantum mechanics
Summary. The justification, brief description and development stages of a system of automatically controlled large‐scale plasma protein fractionation is presented. In this process a continuous stream of plasma and its precipitated fractions are maintained in circumstances of maximum safeguard whilst being subjected to closely controlled manipulation of the five standard variables of organic solvent precipitation. Early fractionation results, obtained while operating at a plasma flow‐rate of 15 l/h, are presented and their significance is discussed. Proposed future developments designed to remove the deficiencies of the existing system arc presented and the expected effects of such development are considered.