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Direct Antiglobulin Consumption Test: Tests on Leucocytes and Platelets from Patients with Malignant Disease and Some Observations on Quantitation
Author(s) -
Culley G. A.,
Chalmers D. G.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb04733.x
Subject(s) - platelet , antibody , immunology , gamma globulin , globulin , medicine , malignant disease , coombs test , disease , cancer
Summary. Using the direct antiglobulin consumption test the leucocytes and platelets of 50 patients suffering from disseminated malignant disease have been tested for the presence of a coating gamma globulin. There was a positive incidence of approximately 50%. In 15 control normal subjects no positive results were obtained. No relationship was found between the presence of the globulin and either the type of neoplasm, the amount of radiation or the amount of transfusion. Elution experiments carried out failed to establish whether the globulin has antibody properties or specificity. A comparison of different methods of antiglobulin consumption suggests that this test is not reliable for the quantitative assessment of fixed antibody globulin.