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Autoradiographic Studies of Human Chromosomes
Author(s) -
German J. L.,
Walker M. E.,
Stiefel F. H.,
Allen F. H.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb04726.x
Subject(s) - locus (genetics) , long arm , karyotype , biology , genetics , chromosome analysis , chromosome , aneuploidy , cytogenetics , microbiology and biotechnology , gene
Summary. Cytogenetic analysis combined with blood grouping in a phenotypically abnormal child and his family suggest that the MN locus is in the long arm of either chromosome No. 2 or chromosome No. 4. The propositus, who is type M, appears to be hemizygous at the MN locus, or has a condition that cannot be distinguished from hemizygous by serological methods. The father, who is type N, is homozygous N/N by dosage estimations. The caryotype of the propositus is 46,XY,t(2q‐; 4q +). About one‐half of the distal part of the long arm of a No. 2 has been translocated to the distal end of the long arm of a No. 4.