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Saline Anti‐Rh(D) and Haemolytic Disease of the Newborn
Author(s) -
Hopkins D. F.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb04713.x
Subject(s) - haemolytic disease , saline , medicine , titer , disease , fetus , antibody , immunology , pregnancy , biology , genetics
Summary. The majority of Rh(D) negative immunised mothers have some saline agglutinating anti‐D in their sera during subsequent pregnancies. This saline antibody is related to a complex effect on the severity of haemolytic disease of the foetus: the stillbirth rate is reduced while the severity of disease among liveborn infants increases slightly with rising titres of saline anti‐D. Also, when the observed saline anti‐D titre is I the severity of disease is markedly incresed while the protective effect of saline anti‐D on the stillbirth rate fails to operate. The significance of this is discussed. Mothers of group A and especially group B are more liable to form saline anti‐D, while the severity of HDN increases if the mother is of group B or AB.