Premium
Rapid Clearance of Rh Positive Blood During Experimental Rh Immunisation
Author(s) -
Woodrow J. C.,
Finn R.,
Krevans J. R.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb00407.x
Subject(s) - rh blood group system , medicine , isoantibodies , antibody , immunization , gamma globulin , antigen , immunology
Summary. When Rh negative male volunteers were given successive small injections of Rh positive blood, it was repeatedly found that rapid clearance of the cells took place in the absence of detectable antibody. It is thought likely that primary immunisation to the D (Rh o ) antigen had occurred in these cases and that a similar state occurs as a result of Rh positive pregnancies in Rh negative mothers. These findings have a relevance to the assessment of trials in which gammaglobulin anti‐D is given to prevent Rh immunisation.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom