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Effect of Interferon on the Course of Spontaneous and Radiation‐Induced Renal Lesions in the RF/Un Mouse 1
Author(s) -
Guttman P. H.,
Davis W. C.,
Fudenberg H. H.,
Merigan T. C.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb00397.x
Subject(s) - interferon , murine leukemia virus , leukemia , myeloid leukemia , myeloid , immunology , myeloid cells , virus , medicine , biology , cancer research , virology
Summary. A spontaneous form of progressive intercapillary glomerulosclerosis (IGS) develops in RF/Un mice in early life and is accelerated by neonatal irradiation. The lesions are similar to those seen in mice with viral infections and may be of viral origin. In the present study, daily injection of the antiviral agent interferon appeared to retard the course of both spontaneous and radiation‐induced IGS in RF/Un mice. In addition, the occurrence of the lesions was independent of the occurrence of myeloid leukemia, suggesting that if IGS is viral mediated, the virus is different from the agent responsible for the high incidence of myeloid leukemia in mice of the RF/Un strain.