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HL—A Antigens and Genes
Author(s) -
Thorsby E.
Publication year - 1969
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1969.tb00377.x
Subject(s) - locus (genetics) , allele , genetics , null allele , biology , gene
Summary. To obtain information about the genetic basis of the HL‐A system, 299 unrelated Norwegians were examined with HL‐A antisera. The results indicated that the HL‐A antigens are determined by multiple mutually exclusive genes at two sub‐loci, the LA sub‐locus and the 4 sub‐locus. Four alleles could be identified at the LA sub‐locus: LA1, LA2, LA3 and LA‐BS. Additional alleles exist at this sub‐locus, with a frequency of 0.2572 in this material. Five alleles were found at the 4 sub‐locus: MH, TT, HN, 7C and 7D. Additional alleles also exist at this sub‐locus; the frequency of this ‘null’ allele was calculated to be 0.4565.