Premium
Studies on Agglutination by Macromolecular Antibodies
Author(s) -
Tönder O.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb04619.x
Subject(s) - agglutination (biology) , antibody , hemagglutination , lability , antiserum , hemagglutination assay , antigen , chemistry , immune sera , neutralization , immunology , microbiology and biotechnology , biology , biochemistry , titer
Summary. Hemagglutination by γM‐antibodies is inhibited by fresh serum, particularly rabbit and horse sera. The antibodies react with the erythrocytes and are not eluted from them in the presence of the inhibitor. The inhibitor combines firmly with the γM‐sensitized erythrocytes and blocks the second‐stage agglutination by agglutinator. Inhibiting activity is increased in some immune sera, particularly in rabbit antisera to human serum. Hemagglutination by γG‐antibodies is not affected. The heat lability and the reactivity with antigen‐antibody complexes indicated that the inhibitor is of complement nature, possibly related to C'lq.