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Antigens on Human Fibroblasts Demonstrated with HL‐A Antisera and Anti‐Human Lymphocytic Sera
Author(s) -
THORSBY E.,
LIE S.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb04446.x
Subject(s) - antiserum , antigen , heterologous , cytotoxic t cell , in vitro , pan t antigens , biology , immunology , fibroblast , histocompatibility , transplantation , tissue typing , microbiology and biotechnology , human leukocyte antigen , medicine , genetics , gene
Summary. Fibroblasts cultured from the skin of six persons were typed with cytotoxic iso‐antisera detecting several of the human HL‐A antigens. A nearly complete concordance with the outcome of lymphocyte‐typing of the same persons was found; HL‐A antigens are thus present on human fibroblasts. This signifies a wide distribution of HL‐A antigens in human tissues, and supports the conception of HL‐A antigens being important transplantation antigens in man. The fibroblasts were also examined with some heterologous anti‐human lymphocytic sera. It was found that these antisera were cytotoxic against human fibroblasts, which demonstrates lack of cell specificity in vitro of such antisera.