Premium
A New Inherited Serum Beta‐Lipoprotein Antigen in Man and its Relation to the Ag(xy) System
Author(s) -
Contu L.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb04077.x
Subject(s) - antigen , gene , antibody , lipoprotein , beta (programming language) , chemistry , biology , immunology , microbiology and biotechnology , endocrinology , biochemistry , cholesterol , computer science , programming language
Summary. A new anti‐Ag serum, R. M., which reacts against an antigen present in about 42% of unrelated Caucasian individuals has been discovered. This antigen, provisionally called Ag(m), is controlled by an autosomal dominant gene, and it seems to occur in all sera positive to serum L.L. and be lacking in all sera negative to serum L.L. However the antibody specificities of these two anti‐Ag sera are not identical. Two different beta‐lipoprotein molecules are precipitated by serum L.L., only one of which is precipitated by serum R.M. It seems that serum L.L. has both the anti‐x and the anti‐m specificities. The relation between Ag(x) and Ag(m) factors is, at present, not entirely clear. It is possible that these factors are produced by the same gene or by two very closely linked genes.