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Anti‐IP 1 : Antibodies that Show an Association Between the I and P Blood Group Systems 1
Author(s) -
Issitt P. D.,
Tegoli J.,
Jackson Valerie,
Sanders C. W.,
Allen F. H.
Publication year - 1968
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1968.tb01697.x
Subject(s) - antibody , antigen , blood group antigens , isoantigens , isoantibodies , immunology , microbiology and biotechnology , medicine , biology
Summary. In a study of four antibodies originally thought to be anti‐P 1 , two different specificities have been demonstrated. Anti‐P 1 agglutinates P 1 + bloods whether or not they are I +, while anti‐IP 1 reacts with 1 + P 1 + but not with I– P 1 + cells. It appears that anti‐IP 1 is directed not against the P 1 antigen but against an antigenic determinant produced by the actions of both the P 1 and I genes. Because bloods from newborn infants give weak or negative reactions with anti‐IP 1 , it is important that ‘anti‐P’ used for testing newborns be shown to be really anti‐P 1 and not anti‐IP 1 .