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On the Presence of γG and β1C Globulins in Renal Glomeruli of Aging and Neonatally X‐Irradiated Mice 1
Author(s) -
Guttman P. H.,
Wuepper K. D.,
Fudenberg H. H.
Publication year - 1967
Publication title -
vox sanguinis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.68
H-Index - 83
eISSN - 1423-0410
pISSN - 0042-9007
DOI - 10.1111/j.1423-0410.1967.tb03363.x
Subject(s) - pathogenesis , antibody , glomerulosclerosis , gamma globulin , autoimmunity , kidney , globulin , immunology , pathology , biology , endocrinology , medicine , proteinuria
Summary The presence of γG‐ and β1C‐globulin was demonstrated in the renal lesions of progressive intereapillary glomerulosclerosis (IGS) of aging and irradiated mice by means of fluorescent antibody techniques. The extent of deposits and intensity of fluorescence paralleled the severity of the disease. Evidence is presented that these deposits may represent local complexes of antigen‐antibody and complement. The possible role of ‘autoimmunity’ in the pathogenesis of the kidney lesions in aging and irradiated mice is considered in light of present studies and previous observations.