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The effect of a population bottleneck on the evolution of genetic variance/covariance structure
Author(s) -
JARVIS J. P.,
CROPP S. N.,
VAUGHN T. T.,
PLETSCHER L. S.,
KINGELLISON K.,
ADAMSHUNT E.,
ERICKSON C.,
CHEVERUD J. M.
Publication year - 2011
Publication title -
journal of evolutionary biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.289
H-Index - 128
eISSN - 1420-9101
pISSN - 1010-061X
DOI - 10.1111/j.1420-9101.2011.02347.x
Subject(s) - biology , covariance , epistasis , population bottleneck , population , bottleneck , genetic correlation , evolutionary biology , effective population size , genetic variation , statistics , genetics , mathematics , allele , gene , demography , sociology , computer science , microsatellite , embedded system
It is well known that standard population genetic theory predicts decreased additive genetic variance ( V a ) following a population bottleneck and that theoretical models including interallelic and intergenic interactions indicate such loss may be avoided. However, few empirical data from multicellular model systems are available, especially regarding variance/covariance (V/CV) relationships. Here, we compare the V/CV structure of seventeen traits related to body size and composition between control (60 mating pairs/generation) and bottlenecked (2 mating pairs/generation; average F = 0.39) strains of mice. Although results for individual traits vary considerably, multivariate analysis indicates that V a in the bottlenecked populations is greater than expected. Traits with patterns and amounts of epistasis predictive of enhanced V a also show the largest deviations from additive expectations. Finally, the correlation structure of weekly weights is not significantly different between control and experimental lines but correlations between necropsy traits do differ, especially those involving the heart, kidney and tail length.