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Intravenous fluorescein as a cause of immunoglobulin E‐mediated anaphylactic shock
Author(s) -
BREIDABLIK A.,
PATER G. H.,
WALTHER C.,
NOPP A.,
GUTTORMSEN A. B.
Publication year - 2012
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2012.02732.x
Subject(s) - medicine , fluorescein , immunoglobulin e , anaphylactic shock , histamine , anaphylaxis , immunology , shock (circulatory) , basophil , allergen , antibody , tryptase , allergy , mast cell , pharmacology , fluorescence , physics , quantum mechanics
We report a patient with severe anaphylactic shock immediately after injection of i.v. fluorescein. The patient recovered without sequela. Immunoglobulin E ( IgE ) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity ( CD ‐sens) and histamine release tests towards fluorescein. This is, to our knowledge, the first report where CD ‐sens has been used to aid in diagnosing an IgE ‐mediated anaphylactic shock caused by fluorescein.