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Propofol reduces early post‐operative pain after gynecological laparoscopy
Author(s) -
LI M.,
MEI W.,
WANG P.,
YU Y.,
QIAN W.,
ZHANG Z. G.,
TIAN Y. K.
Publication year - 2012
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2011.02603.x
Subject(s) - medicine , propofol , pacu , anesthesia , bispectral index , analgesic , shivering , nausea , vomiting , postoperative nausea and vomiting , emergence delirium , randomized controlled trial , sevoflurane , surgery
Background There is some evidence that propofol may reduce post‐operative pain. However, the results on the analgesic effects of propofol are inconsistent. Thus, we hypothesized that propofol reduces acute pain if confounding factors like opioids are avoided. Methods In this prospective, randomized, subject‐ and assessor‐blind, parallel‐group, head‐to‐head comparative study, 90 A merican S ociety of A nesthesiologists I or II females underwent elective laparoscopies were randomized to receive either propofol‐based ( PR ), or sevoflurane‐based ( SR ), or sevoflurane‐propofol‐based anesthesia ( SPR ). Pain score at rest assessed by a numerical rating scale at 0.5 h after surgery was the primary outcome. The secondary outcomes included pain score at 1 and 24 h post‐operatively, duration of post‐anesthesia care units stay ( PACU ), incidence of post‐operative nausea and vomiting, incidence of shivering, and post‐operative quality of recovery score ( QoR ‐40) within the first 24 h post‐operatively. Results No patients received rescue analgesia. The pain score at 0.5 h post‐operatively was less in group PR when compared with group SR (0.7 ± 1.4 vs. 2.1 ± 1.8; P = 0.010) or group SPR (0.7 ± 1.4 vs. 2.1 ± 2.2; P = 0.008). Group PR was also associated with shorter PACU stay than group SR (21.8 ± 5.7 vs. 26.2 ± 6.9; P = 0.050) or group SPR (21.8 ± 5.7 vs. 27.8 ± 8.9; P = 0.005). Intraoperative bispectral index values, hemodynamic values and post‐operative QoR ‐40 scores did not differ among the three groups. Conclusions Propofol anesthesia was associated with significantly less pain at 0.5 and 1 h after surgery in patients undergoing gynecological laparoscopies with planned opioid‐free post‐operative analgesia.