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The association between early hemodynamic variables and outcome in normothermic comatose patients following cardiac arrest
Author(s) -
TORGERSEN C.,
SCHMITTINGER C. A.,
TAKALA J.,
JAKOB S. M.,
DÜNSER M. W.
Publication year - 2010
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2010.02273.x
Subject(s) - medicine , hemodynamics , anesthesia , association (psychology) , cardiology , epistemology , philosophy
Background: Currently, few data exist on the association between post‐cardiac arrest hemodynamic function and outcome. In this explorative, retrospective analysis, the association between hemodynamic variables during the first 24 h after intensive care unit admission and functional outcome at day 28 was evaluated in 153 normothermic comatose patients following a cardiac arrest. Methods: Medical records of a multidisciplinary intensive care unit were reviewed for comatose patients (Glasgow Coma Scale ≤9) admitted to the intensive care unit after successful resuscitation from an in‐ or an out‐of‐hospital cardiac arrest. The hourly variable time integral of hemodynamic variables during the first 24 h after admission was calculated. At day 28, outcome was assessed as favorable or adverse based on a Cerebral Performance Category of 1–2 and 3–5, respectively. Bi‐ and multivariate regression models adjusted for relevant confounding variables were used to evaluate the association between hemodynamic variables and functional outcome. Results: One hundred and fifty‐three normothermic comatose patients were admitted after a cardiac arrest, of whom 64 (42%) experienced a favorable outcome. Neither in the adjusted bivariate models ( r 2 , 0.61–0.78) nor in the adjusted multivariate model ( r 2 , 0.62–0.73) was the hourly variable time integral of any hemodynamic variable during the first 24 h after intensive care unit admission associated with functional patient outcome at day 28 in all patients as well as in patients after an in‐ or an out‐of‐hospital cardiac arrest. Conclusion: Commonly measured hemodynamic variables during the first 24 h following intensive care unit admission due to a cardiac arrest do not appear to be associated with the functional outcome at day 28.