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Time course of rocuronium‐induced neuromuscular block after pre‐treatment with magnesium sulphate: a randomised study
Author(s) -
CZARNETZKI C.,
LYSAKOWSKI C.,
ELIA N.,
TRAMÈR M. R.
Publication year - 2010
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2009.02160.x
Subject(s) - rocuronium , medicine , saline , anesthesia , magnesium , propofol , sufentanil , placebo , neuromuscular transmission , chemistry , alternative medicine , organic chemistry , pathology
Background: A previously published study suggested that pre‐treatment with magnesium sulphate (MgSO 4 ) had no impact on the speed of onset of rocuronium‐induced neuromuscular block. We set out to verify this assumption. Methods: Eighty patients (18–60 years) were randomly allocated to MgSO 4 60 mg/kg or placebo (saline). Study drugs were given intravenously for 15 min before induction of anaesthesia with propofol, sufentanil and rocuronium 0.6 mg/kg. Anaesthesia was maintained with a target‐controlled propofol infusion. Neuromuscular transmission was measured using train‐of‐four (TOF)‐Watch SX ® acceleromyography. Results: Onset was analysed in 37 MgSO 4 and 38 saline patients, and recovery in 35 MgSO 4 and 37 saline patients. Onset time (to 95% depression of T1) was on average 77 [SD=18] s with MgSO 4 and 120 [48] s with saline ( P <0.001). The total recovery time (DurTOF0.9) was on average 73.2 [22] min with MgSO 4 and 57.8 [14.2] min with saline ( P <0.003). The clinical duration (Dur25%) was on average 44.7 [14] min with MgSO 4 and 33.2 [8.1] min with saline ( P <0.0002). The recovery index (Dur25–75%) was on average 14.0 [6] min with MgSO 4 and 11.2 [5.2] min with saline ( P <0.02). The recovery time (Dur25%TOF0.9) was on average 28.5 [11.7] min with MgSO 4 and 24.7 [8.4] min with saline ( P =0.28). Conclusion: Magnesium sulphate given 15 min before propofol anaesthesia reduces the onset time of rocuronium by about 35% and prolongs the total recovery time by about 25%. Trial Registration: Clinicaltrials.gov identifier: NCT00405977.