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Surface vs. aortic flush cooling during cardiac arrest in pigs
Author(s) -
SCHRATTER A.,
WEIHS W.,
JANATA A.,
BAYEGAN K.,
HOLZER M.,
STERZ F.,
BEHRINGER W.
Publication year - 2010
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2009.02113.x
Subject(s) - medicine , hypothermia , ventricular fibrillation , saline , anesthesia , cardiology
Background: To investigate the feasibility and efficacy of earlier induction of hypothermia already during the ‘no‐flow’ period of cardiac arrest with non‐invasive surface cooling or invasive aortic flush cooling. Methods: This was a prospective randomized experimental study that included 14 pigs, Large White breed (30–38 kg), with ventricular fibrillation cardiac arrest plus blanket surface and an invasive cold saline flush cooling. The endpoint was a decline in brain temperature ( T br ) at 35 min after cardiac arrest. Results: With surface cooling, T br decreased from 38.7±0.2 °C to 37.4±0.8 °C ( P =0.02) and with invasive cooling T br decreased from 38.8±0.13 °C to 19.0±2.8 °C within 216±23 s ( P =0.02) and increased back to 33.0±0.6 °C at 35 min of cardiac arrest ( P =0.02 vs. T br at 15 min, P =0.002 vs. T br at 35 min in the surface cooling groups). Conclusion: Invasive cooling by aortic flush with cold saline rapidly induces deep cerebral hypothermia, whereas non‐invasive surface cooling only marginally decreases brain temperature.