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An anaphylactic reaction to transdermal delivered fentanyl
Author(s) -
DEWACHTER P.,
LEFEBVRE D.,
KALABOKA S.,
BLOCHMOROT E.
Publication year - 2009
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2009.02022.x
Subject(s) - medicine , transdermal , fentanyl , anesthesia , anaphylactic reaction , anaphylactic reactions , anaphylaxis , pharmacology , allergy , immunology
Immediate allergic hypersensitivity reactions with fentanyl are rarely reported. We diagnosed a presumably IgE‐mediated allergic hypersensitivity reaction comprising generalized erythema and bronchospasm 4 h after the first‐time application of transdermal fentanyl. Prick test remained negative with fentanyl whereas an intradermal test (IDT) with fentanyl was positive (dilution 10 −2 ). Cross‐reactivity was found with sufentanil but not with remifentanil. The diagnosis was supported by the clinical history and a positive IDT with fentanyl. This case report confirms the need for a systematic allergological investigation in case of immediate hypersensitivity reactions for all drugs and all modes of administration.