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Correlation between central venous oxygen saturation and oxygen delivery changes following fluid therapy
Author(s) -
YAZIGI A.,
ABOUZEID H.,
MADIJEBARA S.,
HADDAD F.,
HAYEK G.,
JABBOUR K.
Publication year - 2008
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2008.01761.x
Subject(s) - medicine , central venous pressure , mean arterial pressure , anesthesia , hemodynamics , cardiology , blood pressure , oxygen saturation , cardiac index , cardiac output , oxygen , heart rate , chemistry , organic chemistry
Background: The rationale for using central venous oxygen saturation (ScvO 2 ) in various clinical scenarios is that it reflects the balance between oxygen delivery (DO 2 ) and demands. In this study, we evaluated the correlation between ScvO 2 and DO 2 changes (ΔDo 2 , ΔScvO 2 ) in patients receiving fluid therapy following coronary surgery. We also correlated the changes of mean arterial pressure (ΔMAP) and central venous pressure (ΔCVP), with ΔDO 2 . Methods: Sixty consecutive sedated and mechanically ventilated adult patients, with cardiac index ≤2.3 L/min/m 2 and a pulmonary artery occlusion pressure ≤12 mmHg following coronary surgery, were included. Concomitant hemodynamic parameters, arterial and venous blood gases were measured before (T0) and after (T1) administration of a 500 ml bolus of an isotonic crystalloid solution over 30 min. The correlations between ΔDO 2 and ΔScvO 2 , ΔMAP or ΔCVP were evaluated by linear regression analysis and Pearson test. Results: Cardiac index (1.9±0.2 vs 2.3±0.5 ml/min/m 2 ), MAP (83±11 vs 94±13mmHg) and CVP (5.7±3 vs 7.1±3 mmHg) were significantly higher at T1 compared with T0. The correlation of ΔDO 2 with ΔScvO 2 was positive, significant ( r =0.41; P =0.004) and superior to its correlation with ΔMAP (r=0.30; P =0.01) or ΔCVP ( r =0.03; P =0.78). Conclusion: A significant correlation between ScvO 2 and DO 2 changes was found in patients receiving fluid therapy following coronary surgery. ScvO 2 could be used as an indicator to track DO 2 and to guide volume loading.