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Low‐dose haloperidol prevents post‐operative nausea and vomiting after ambulatory laparoscopic surgery
Author(s) -
WANG T. F.,
LIU Y. H.,
CHU C. C.,
SHIEH J. P.,
TZENG J. I.,
WANG J. J.
Publication year - 2008
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2007.01525.x
Subject(s) - droperidol , medicine , anesthesia , ambulatory , haloperidol , postoperative nausea and vomiting , saline , placebo , vomiting , nausea , antiemetic , surgery , alternative medicine , pathology , dopamine
Background: We evaluated the prophylactic effect of low‐dose haloperidol (1 mg) on post‐operative nausea and vomiting (PONV) in women undergoing ambulatory laparoscopic surgery. Droperidol (0.625 mg) and saline were controls. Methods: One hundred and fifty women undergoing ambulatory laparoscopic surgery under general anaesthesia were enrolled in this randomized, double‐blind, and placebo‐controlled study. After tracheal intubation, the haloperidol group ( n =50) received intravenous haloperidol (1 mg), the droperidol group ( n =50) received intravenous droperidol (0.625 mg), and the saline group ( n =50) received intravenous saline. Results: Haloperidol‐ and droperidol‐group patients reported a lower incidence of PONV [24% and 23% vs. 49% (saline group); P <0.05] and requested fewer doses of rescue antiemetics [13% and 16% vs. 38% (saline group); P <0.05] during the first four post‐operative hours. During the 24‐h post‐operative period, haloperidol‐ and droperidol‐group patients also reported a lower incidence of PONV [31% and 32% vs. 62% (saline group); P <0.01]. No differences were found between the haloperidol and droperidol groups. Conclusion: Like droperidol (0.625 mg), prophylactic intravenous haloperidol (1 mg) significantly reduced the incidence of PONV in women undergoing ambulatory laparoscopic surgery.