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The post‐operative analgesic effects of a combination of gabapentin and paracetamol in patients undergoing abdominal hysterectomy: a randomized clinical trial
Author(s) -
Durmus M.,
Kadir But A.,
Saricicek V.,
Ilksen Toprak H.,
Ozcan Ersoy M.
Publication year - 2007
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2006.01237.x
Subject(s) - medicine , gabapentin , anesthesia , sedation , placebo , nausea , analgesic , visual analogue scale , vomiting , morphine , propofol , abdominal surgery , randomized controlled trial , surgery , alternative medicine , pathology
Background: The aim of the present study was to compare the effects of a combination of gabapentin and paracetamol with gabapentin alone and placebo on post‐operative pain and morphine consumption. Methods: Seventy‐five ASA I–II patients undergoing abdominal hysterectomy were included in the study and randomly divided into three groups. Placebo capsules (Group I, n = 25), 1200 mg of gabapentin (Group II, n = 25), or 1200 mg of gabapentin and 20 mg/kg paracetamol in combination (Group III, n = 25) were administered 1 h prior to surgery. Anaesthesia was standardized for all patients. Non‐invasive arterial pressure, heart rate, respiratory rate, peripheral oxygen saturation, morphine consumption, nausea and vomiting, visual analogue scale‐pain intensity scores (VAS‐PI) and sedation scores were recorded at 1, 2, 4, 6 and 24 h following the operation. Results: Morphine consumption at 24 h was 66.60 ± 11.49 mg, 42.74 ± 12.33 mg and 30.50 ± 11.55 mg, respectively, in groups I, II and III ( P < 0.05). Post‐operative VAS‐PI scores at movement and at rest were decreased with gabapentin and even more with a combination of gabapentin and paracetamol. Post‐operative sedation scores were higher in groups II and III during the initial 4 h while these scores were higher in group I at 24 h. Conclusions: The single dose of gabapentin as well as a combination of gabapentin and paracetamol decreased the opioid requirement and increased the patients’ satisfaction post‐operatively.