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Efficacy of sufentanil addition to ropivacaine epidural anaesthesia for Caesarean section
Author(s) -
BachmannMennenga B.,
Veit G.,
Steinicke B.,
Biscoping J.,
Heesen M.
Publication year - 2005
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2005.00657.x
Subject(s) - medicine , ropivacaine , sufentanil , caesarean section , anesthesia , regional anaesthesia , elective caesarean section , pregnancy , biology , genetics
Background: This prospective double‐blind trial evaluated the effect of sufentanil addition to epidural ropivacaine for elective Caesarean section. Methods: Sixty healthy parturients were randomly assigned to receive an initial dose of 90 mg of plain ropivacaine, or 90 mg of ropivacaine plus 10 or 20 µg of sufentanil ( n = 20 each). Before surgery, if necessary, additional epidural ropivacaine was injected. Primary outcome parameter was time to achieve sensory block at T4. Results: Time to reach the sensory block was remarkably reduced ( P < 0.001 each) by addition of 10 or 20 µg of sufentanil (21 ± 8 min, 15 ± 5 min, 11 ± 4 min in the plain ropivacaine, the 10‐ and 20‐µg sufentanil groups, respectively) whereas the visual analogue scale (VAS) scores at delivery were significantly reduced ( P = 0.028) only by 20 µg of sufentanil (32 ± 35 mm in the plain ropivacaine vs. 9 ± 19 mm in the 20‐µg sufentanil groups). The total dose of ropivacaine was significantly lower ( P = 0.005) in patients receiving 20 µg of sufentanil (100.5 ± 15.0 mg) compared with those treated with plain ropivacaine (118.5 ± 17.3 mg). The incidence of maternal side‐effects (hypotension, bradycardia, nausea, vomiting, shivering, pruritus) and neonatal outcome [APGAR score, neurologic and adaptive capacity (NAC) score, umbilical cord blood‐gas values] did not differ between the groups. Conclusion: Our results suggest that addition of 20 µg of sufentanil improved the epidural anaesthesia with ropivacaine 0.75% for Caesarean section.