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Preemptive effect of intravenous ketamine in the rat: Concordance between pain behavior and spinal fos‐like immunoreactivity
Author(s) -
Lee IH.,
Lee IO.
Publication year - 2005
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2004.00568.x
Subject(s) - medicine , ketamine , concordance , anesthesia , neuroscience , biology
Background: The purpose of this study was to compare behavioral antinociceptive responses with spinal fos‐like immunoreactivity (FLI) for a intravenous ketamine injection between pre vs. postformalin administration in rats. Methods: Sprague‐Dawley rats (250–300 g) were prepared to receive either saline or ketamine. All rats were randomly divided into three groups: control, pretreatment and post‐treatment group. Formalin (5%) 100 µl was injected into the hindpaw. Pain related behavior and FLI in the lumbar spinal cord was examined. Results: Flinches of phase 2 were 239.3 (22,8), 118.6 (7,5) ( P < 0.05 vs. control and post‐treatment group), and 186.7 (16,6) in the control, pre and, post‐treatment groups, respectively. Fos‐like immunoreactivity expression was significantly correlated with phase 2 flinching behavior ( P < 0.001). Conclusion: Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia.