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Effect of ephedrine on the onset time of succinylcholine
Author(s) -
Ganidagli S.,
Cengiz M.,
Baysal Z.
Publication year - 2004
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2004.00529.x
Subject(s) - medicine , anesthesia , ephedrine , propofol , fasciculation , heart rate , intubation , muscle relaxation , remifentanil , tracheal intubation , blood pressure
Background: The aim of this study was to evaluate the effect of ephedrine administered prior to induction of anaesthesia on the onset time of succinylcholine for endotracheal intubation. Methods: Patients were randomly assigned to receive intravenously (i.v.) either 70 µg kg −1 of ephedrine (Group I; n = 25) or saline (Group II; n = 25) 3 min before induction of anaesthesia. Induction of anaesthesia was provided with propofol 2 mg kg −1 plus remifentanil 1 µg kg −1 . Onset time and duration of muscle fasciculation and onset time of succinylcholine were recorded. Intubation was attempted after establishment of 100% thumb relaxation and difficulties were recorded. Heart rate, pulse oxymetry (SpO 2 ) and mean arterial pressure (MAP) were also recorded. Results: The onset time of succinylcholine were significantly ( P < 0.001) shorter in Group I (26 ± 4 s), when compared with Group II (43 ± 6 s). Patients in Group I were intubated at 49 ± 7 s compared with 68 ± 10 s in Group II. The score of intubation was similar in both groups. Duration of muscle fasciculation was longer in Group II. Heart rate and MAP increased significantly ( P < 0.05) after ephedrine injection, compared with the baseline value in Group I. Conclusions: The onset time of succinylcholine can be shortened with ephedrine pretreatment.