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Comparison of the analgesic efficacy of ketobemidone and morphine for management of postoperative pain in children: a randomized, controlled study
Author(s) -
Jylli L.,
Lundeberg S.,
LangiusEklöf A.,
Olsson G. L.
Publication year - 2004
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2004.00524.x
Subject(s) - medicine , analgesic , morphine , adverse effect , anesthesia , potency , randomized controlled trial , surgery , biochemistry , chemistry , in vitro
Background: Ketobemidone has been used as an analgesic for postoperative pain in children, but to our knowledge the effect and occurrence of adverse effects of ketobemidone compared to morphine is not known. The aim was to determine if the analgesic potency and the occurrence of adverse effects of ketobemidone differ from morphine when administered to children, as measured by patient‐controlled analgesia consumption (PCA) for postoperative pain. Methods: Sixty healthy children, aged 6 to 16 years, scheduled for elective surgery were randomized to receive either ketobemidone (Ke) 1 mg ml −1 or morphine (Mo) 1 mg ml −1 for postoperative pain through PCA. Drug consumption (µg kg −1 h −1 ), the number of PCA doses, pain intensity, and adverse effects were recorded at regular intervals. Results: Data on total drug consumption were based on 26 children in the Ke group and 28 in the Mo group. A non‐statistically significant difference for total mean consumption of ketobemidone (18.6 µg kg −1 h −1 ) and morphine (23.2 µg kg −1 h −1 ) was obtained. The mean dose ratio (Mo/Ke) was 0.80 and the median was 0.94. Children's characteristics, loading dose, PCA doses, VAS scores, and adverse effects showed no significant differences between the groups. Conclusion: The analgesic potency and adverse effects of ketobemidone are similar to morphine when used for postoperative pain management in children.