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Adverse biochemical and physiological effects of prostacyclin in experimental brain oedema
Author(s) -
Gärdenfors F.,
Nilsson A.,
Ungerstedt U.,
Nordström C. H.
Publication year - 2004
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.2004.00522.x
Subject(s) - medicine , microdialysis , prostacyclin , intracranial pressure , anesthesia , cerebral edema , ischemia , endocrinology , central nervous system
Background: Prostacyclin (PGI 2 ) and its stable analogues are known to reduce capillary hydraulic permeability. This study explores the biochemical and physiological effects of i.v. infusion of low‐dose PGI 2 in an experimental model of vasogenic brain oedema. Methods: Twenty‐seven anaesthetized and mechanically ventilated piglets with brain oedema induced by intrathecal injection of lipopolysaccharide (LPS) were used. Five of the animals received a continuous infusion of PGI 2 (1 ng kg −1 min −1 ) i.v. Four microdialysis catheters were placed in the brain to measure interstitial concentrations of glucose, lactate, and glycerol. Mean arterial pressure (MAP), intracranial pressure (ICP) and temperature were monitored continuously. Low‐dose infusion of PGI 2 started 1 h before the LPS injection and was constant during the study period. Results: Intracranial pressure increased significantly in animals treated with PGI 2 . The increase in ICP was associated with significant cerebral biochemical changes: decrease in glucose, increase in lactate, increase in lactate/glucose ratio and increase in glycerol. Conclusion: In LPS‐induced brain oedema i.v. infusion of low‐dose PGI 2 caused a further increase in ICP and a perturbation of energy metabolism, indicating cerebral ischemia and degradation of cellular membranes.