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Thyroid function during and after cardiopulmonary bypass in children
Author(s) -
Saatvedt K.,
Lindberg H.,
Geiran O. R.,
Fiane A.,
Seem E.,
Michelsen S.,
Pedersen T.,
Hagve T. A.
Publication year - 1998
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1998.tb05384.x
Subject(s) - medicine , cardiopulmonary bypass , thyroid , thyroid function , heart disease , hormone , cardiac surgery , anesthesia , surgery
Background: The aim of the study was to elucidate the changes in thyroid function during and after cardiopulmonary bypass (CPB) in children. Methods: Triiodothronine (T3), thyroxine (T4), free thyroxine (FT4) and thyroid‐stimulating hormone (TSH) were determined preoperatively, at specific times throughout CPB, and serially up to 48 h postoperatively, in 10 children (median age 35, range 23–68 months) undergoing elective surgery for congenital heart disease. Results: T3 decreased from 2.01±0.08 preoperatively to 0.94±0.10 nmol/1 24 h postoperatively ( P <0.05). T4 levels followed a pattern similar to changes in T3. FT4 increased from 17.4±0.7 preoperatively to 30.0±0.4 pmol/1 after 30 min of CPB ( P <0.05). TSH decreased from 2.44±0.43 preoperatively to 0.93±0.21 24 h postoperatively ( P <0.05). Conclusion: T3, T4 and TSH are significantly depressed after open heart surgery in children.