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Stability of local anesthetics in heparinized blood, plasma and sulfuric acid
Author(s) -
Adams H. A.,
Pawlik D.,
Bauer H.,
Mautgreve W.
Publication year - 1998
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1998.tb05322.x
Subject(s) - mepivacaine , medicine , prilocaine , anesthesia , bupivacaine , lidocaine , surgery
Background : This study was undertaken to investigate the stability of local anesthetics in different media. Methods : 60 patients with axillary plexus block, using prilocaine, mepivacaine or lidocaine 1%, or with lumbar epidural catheter‐anesthesia, using bupivacaine 0.5%, were investigated. Stability was evaluated in heparinized whole blood for 24 h at +4°C, in plasma for 8 weeks at –25°C and in sulfuric acid for 6 months at –25°C. Results : Mean recovery rates were between 96.4% and 102.6% in all local anesthetics and media. No statistical significance became obvious for differences between recovery rates and initial values. Conclusion :Stability of prilocaine, mepivacaine, lidocaine and bupivacaine can be expected when samples are stored as heparinized whole blood for 24 h at +4°C, plasma for 8 weeks at –25°C, and after preparation into sulfuric acid for 6 months at –25°C.