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Central and mixed venous blood oxygen correlate well during acute normovolemic hemodilution in anesthetized pigs
Author(s) -
Schou Dr.H.,
DeSa V. Perez,
Larsson A.
Publication year - 1998
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1998.tb05104.x
Subject(s) - medicine , hematocrit , anesthesia , oxygen , oxygen saturation , arterial oxygen tension , venous blood , oxygen tension , lung , chemistry , organic chemistry
Background : Central venous oxygen saturation (S cv O 2 ) and oxygen tension (p cv O 2 ), obtained from the superior vena cava, correlate well with mixed venous (pulmonary arterial) oxygen saturation (S v O 2 ) and tension (p v O 2 ) when the hematocrit is normal. The present study was undertaken to assess whether extreme hemodilution affects this relation. Methods : We compared mixed and central venous blood during graded arterial desaturation (inspired fraction of oxygen (F I O 2 ) between 1.0 and 0.10) in 10 hemodiluted pigs, and in 10 pigs with normal hematocrit (control), during fentanyl‐ketamine‐pancuronium anesthesia and mechanical ventilation. Results : Arterial oxygen saturation decreased from 100% at F I O 2 =1.0 to 44 ± 12% at F I O 2 =0.10 (mean ± SD). Venous oxygen saturation ranged from 3.5% to 97.3%. The regression coefficient between S v O 2 and S cv O 2 was 0.97 (R 2 = 0.93, bias ‐2.4 ± 5.8%) in the hemodiluted and 0.99 (R 2 = 0.97, bias ‐3.0 ± 5.0%) in the control group. Venous oxygen tension values ranged from 0.5 kPa to 9.5 kPa, and the regression coefficient for oxygen tension was 0.94 (R 2 = 0.89, bias ‐0.20 ± 0.47 kPa) in the hemodiluted and 0.99 (R 2 = 0.97, bias ‐0.43 ± 0.48 kPa) in the control group. The regression coefficient for pH was 0.95 in the hemodiluted and 0.98 in the control animals. Conclusion : The findings indicate that also during hemodilution monitoring of central venous blood oxygen may be as useful as monitoring of mixed venous blood oxygen.