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Retardation of pain development: a case of recovery from congenital insensitivity to pain
Author(s) -
ZHOU T.H.,
REN X.H.,
YIN D.L.,
WU Y.L.,
Li M.,
Lu C.Z.,
Wu D.C.,
Wu Y.Q.,
PENG Y.Q.,
WANG Y.P.,
MA L.,
PEI G.
Publication year - 1997
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1997.tb04840.x
Subject(s) - medicine , abnormality , magnetic resonance imaging , sulcus , anesthesia , surgery , radiology , psychiatry
Congenital analgesia is a rare genetic disorder. We report here that a 12‐year‐old boy was able to recover from congenital insensitivity to pain. Neurological examinations revealed that there was a ‘stocking’ distribution of pain decrement on the lower extremities under the patient's knee joints. Magnetic Resonance Imaging (MRI) of his brain showed gyrus thinning with sulcus widening at both sides of the parietal lobe. Southern blot hybridization probed with cDNAs of various opioid receptors did not detect any significant abnormality. Our results suggest that this rare case may not be genetically determined.