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Continuous low‐flow tracheal gas insufflation during partial liquid ventilation in rabbits
Author(s) -
MESZAROS E.,
OGAWA R.
Publication year - 1997
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1997.tb04801.x
Subject(s) - medicine , insufflation , anesthesia , ventilation (architecture) , mean airway pressure , mechanical ventilation , artificial ventilation , arterial blood , airway , blood flow , positive end expiratory pressure , lung , respiratory disease , cardiology , mechanical engineering , engineering
Background: Both partial liquid ventilation (PLV) and tracheal gas insufflation are novel techniques for mechanical ventilation. In this study we examined whether PLV superimposed by continuous low‐flow tracheal gas insufflation (TGI) offers any advantage to the blood gases and lung mechanics in normal‐lung rabbits compared to the use of PLV only. Methods: Eighteen anesthetized, paralyzed and mechanically ventilated rabbits were used. After obtaining a baseline PaCO 2 value between 29 and 39 mmHg (3.9 and 5.2 kPa), the animals were assigned to three equal groups according to the ventilation they received ‐ A group: PLV superimposed by TGI; B group: PLV only; and C group: continuous mandatory ventilation (CMV) superimposed by TGI. Serial arterial blood gases, pH and lung mechanics were measured. Results: The animals in each group were hemodynamically stable. In the case of the A group, PaO 2 continuously increased, and PaCO 2 stabilized around 40.8±5.5 mmHg (5.4±0.7 kPa, mean±SD, NS). In the B group, the tendency for PaO 2 to increase was not as definite; PaCO 2 continuously increased from 35.2±2.3 mmHg (4.7±0.3 kPa) to 56.3±12.7 mmHg (7.5±1.7 kPa, P < 0.05) at the end of the experiment. In the C group, PaO 2 and PaCO 2 were stable during the observation period. The superimposition of TGI on PLV did not decrease the airway pressures compared to PLV alone. Conclusion: In summary, continuous low‐flow TGI superimposed on PLV can decrease and stabilize the PaCO 2 elevation caused by the initiation of PLV.