Premium
Effects of dopamine, dopexamine and dobutamine on renal excretory function during experimental sepsis in conscious rats
Author(s) -
PALSSON J.,
RICKSTEN S.E.,
HOULTZ E.,
LUNDIN S.
Publication year - 1997
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1997.tb04705.x
Subject(s) - dobutamine , medicine , renal function , renal blood flow , sepsis , fractional excretion of sodium , mean arterial pressure , saline , hemodynamics , anesthesia , endocrinology , blood pressure , heart rate
Background: Acute renal failure is a frequent complication in human sepsis. Various inotropic drugs are often used to improve central haemodynamics and renal function. The differential preservative role of the most commonly used inotropic drugs on renal function, in this condition, has previously not been extensively studied. The aim of this experimental animal study was therefore to compare the preserving effects of dopamine, dopexamine, dobutamine and saline on renal excretory function, after induction of sepsis in conscious rats. Method: The effects of dopamine (DA) (2.5 μg · kg ‐1 · min ‐1 ; n= 11), dopexamine (DX) (1 μg·kg ‐1 · min ‐1 ; n=10), dobutamine (DB) (5 μg·kg ‐1 · min ‐1 ; n=10) and saline (n=13) on the glom‐erular filtration rate (GFR), urine flow (UF), sodium excretion (SE) and fractional urinary excretion of sodium (FUE Na ) were studied and compared in conscious rats subjected to a 1‐h infusion of live E. coli bacteria (10 9 /h). Results: In the saline‐treated control group, bacteria infusion decreased GFR, UF, SE and FUE Na by 31%, 53%, 51% and 36% respectively, associated with a 16% decrease in mean arterial pressure (MAP), and a 10% increase in heart rate (HR). In the post‐ E. coli treatment period, the fall in MAP was less pronounced with DX compared to both DB and control, while there was no difference between DX and DA. The increase in HR was most pronounced with DB. GFR decreased to a lesser extent with DX compared to DA, DB and control. UF and SE were better maintained with DX compared to DB and control, while there was no difference in FUE Na between the groups. Conclusion: We conclude that dopexamine, to a greater extent than dopamine and dobutamine, improves renal excretory function in experimental septic shock.