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The cytokine response in a patient undergoing surgery for an ACTH‐producing tumor
Author(s) -
HÖHNDORF K.,
TOFT P.,
TBNNESEN E.
Publication year - 1997
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1997.tb04686.x
Subject(s) - medicine , cytokine , cardiopulmonary bypass , glucocorticoid , tumor necrosis factor alpha , thoracotomy , anesthesia , endogeny , surgery , endocrinology
The administration of glucocorticoids has been used to inhibit the cytokine production in patients undergoing cardiac surgery during cardiopulmonary bypass. In this case report the cytokine response in a 43‐year‐old man undergoing operation for an ACTH‐producing lung tumor is presented. There had been clinical symptoms for about 18 months and 8 months before operation elevated serum concentrations of ACTH and cortisol were measured. The patient underwent thoracotomy with removal of the tumor and the cytokine response in relation to surgery was measured as plasma concentrations of IL‐lα, IL‐6, TNFα and TNFβ. With the long‐lasting high endogenous glucocorticoid production low or undetectable cytokine levels were expected in this patient. However, a marked and prolonged IL‐6 and TNFβ response was measured while IL‐1α and TNFα were detectable in only a few samples. The cytokine response in this patient was different from the response normally found in patients undergoing major surgery.