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Metoclopramide reduces the induction dose of propofol
Author(s) -
PAGE V. J.,
CHHIPA J. H.
Publication year - 1997
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1997.tb04676.x
Subject(s) - metoclopramide , propofol , medicine , anesthesia , saline , blockade , vomiting , receptor
Background: Metoclopramide has been shown to reduce the dose of thiopentone required for induction of anaesthesia. When propofol is used, there have been conflicting results with one small study showing a reduction in the anaesthetic dose and one study failing to demonstrate any effect. Methods: Two groups of 30 patients were studied. The patients were randomised to receive either saline 0.03 ml/mg or metoclopramide 0.15 mg/kg 5 min before a manual injection of propofol at a set rate. Results: This study shows a reduction in the dose of propofol required for the induction of general anaesthesia following an intravenous dose of metoclopramide. The induction dose of propofol was reduced by 24%. Conclusions: The mechanism of reduction of propofol dose by metoclopramide is unknown; it may involve GABA or result from a more complex interaction involving dopamine blockade by metoclopramide.