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Decrease in plasma volume from intra‐abdominal trauma in rats is prevented by H 1 but not by H 2 histaminergic blockade
Author(s) -
Larmark M.,
Lisander B.
Publication year - 1996
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1996.tb04396.x
Subject(s) - medicine , blockade , extravasation , histaminergic , anesthesia , mean arterial pressure , cimetidine , blood pressure , heart rate , receptor , pathology
Intra‐abdominal surgery causes plasma extravasation which, in the rat, is prevented by combined histaminergic H 1 and H 2 blockade. We evaluated the relative importance of H 1 and H 2 blockade in this situation. Cloralose‐anaesthetized Wistar rats were subjected to a standardized abdominal trauma. Mean arterial pressure (MAP), heart rate (HR) and haematocrit (Hct) were monitored and plasma volume (PV) was determined before and 1 h after the trauma. Compared to non‐traumatized rats (n=8), the trauma decreased PV and increased Hct (n=8). MAP decreased during the actual trauma, whereas HR remained stable throughout. In animals given cimetidine 25 mg kg ‐1 i.v. just prior to the trauma (n=8), PV, Hct and MAP changed, as in the non‐blocked rats. In contrast, pyrilamine, 10 mg kg ‐1 completely prevented the decrease in PV and the increase in Hct (n=7), but not the decrease in MAP. The findings suggest that a histaminergic HI mechanism is of importance for the plasma loss elicited by intra‐abdominal trauma.