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Mivacurium chloride administration by infusion
Author(s) -
APFELBAUM J. L.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04311.x
Subject(s) - medicine , neuromuscular blockade , anesthesia , cholinesterase , blockade , pharmacology , receptor
As a consequence of its rapid hydrolysis by plasma cholinesterase, mivacurium has a short duration of action, and recovery from neuromuscular blockade is rapid (5–95% twitch recovery= 13–15 min). Mivacurium is easy to titrate to individual patient requirements; the average infusion rate to maintain neuromuscular blockade at 89–99% twitch suppression during N 2 O/opioid anaesthesia is 6–7 μg/kg per min in adults and approximately 14 μg/kg per min in children. There is no evidence of a cumulative effect of mivacurium; recovery is unaffected by dose administered or duration of infusion. These characteristics make mivacurium a very suitable agent for use by infusion.