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Hyperkalaemia associated with haemorrhagic shock in rabbits: mochfication by succinylcholine, vecuroniurn and blood transfusion
Author(s) -
ANTOCNINI J. F.,
MARK K.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04242.x
Subject(s) - medicine , shock (circulatory) , haemorrhagic shock , anesthesia , blood transfusion , intensive care medicine , surgery
In haemorrhagic patients, hyperkalaemia may occur after succinylcholine administration. We investigated in haemorrhagic rabbits whether vecuronium caused hyperkaelemia and if blood transfusion prevented succinylcholine‐induced hyperkalaemia. Rabbits were lightly anaesthetized with halothane/N 2 O and 30‐35 ml/kg blood were withdrawn to cause arterial pH to decrease to ∼ 7.0‐7.1. Group C (n = 12) received 3 ml saline, Group S (n = 13) received succinylcholine lmg/kg. Group V (n = 7) received vecuronium 0.25 mg/kg and Group T (n = 9) was transfused with 10 ml/kg blood 10 min prior to receiving succinylcholine 1 mg/kg. K + analysis was repeated at 5 min, and at 10 min in most animals. Haemorrhage increased K + (mmol·1 ‐1 , mean ± SD): Group C, 3.4±0.3 to 6.8±1.8; Group S, 3.8±0.5 to 6.9±2.3; Group V, 3.8±0.3 to 7.1±1.9; Group T, 3.6±0.5 to 7.6±2.9. K + decreased in Group T (to 5.4±1.8) after blood transfusion. K + increased at 5 min in Group S (to 8.7±2.6) and at 10 min for Group C (to 8.4±1.7) and Group T (to 7.2±2.3). The K + increase at 5 min for Group S (1.8±0.8) was significantly higher than those for Group C (1.0±0.6) or Group V (0.9±0.4), but was not different from that of Group T (1.5±0.7). We conclude that haemorrhage and succinylcholine cause hyperkalaemia in rabbits. Muscle relaxation itself does not appear to be a factor, but transfusion may lessen the hyperkalaemia.