Premium
Differential effects of dobutamine, dopamine, and noradrenaline on splanchnic haemodynamics and oxygenation in the pig
Author(s) -
PRIEBE H.J.,
NOLDGE G. F. E.,
ARMBRUSTER K.,
GEIGER K.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04236.x
Subject(s) - medicine , dobutamine , splanchnic , dopamine , oxygenation , hemodynamics , differential (mechanical device) , anesthesia , differential effects , splanchnic circulation , cardiology , engineering , aerospace engineering
Supranormal oxygen (O 2 ) transport may benefit critically ill patients. Catecholamines are clinically employed for this purpose. However, their effects on splanchnic haemodynamics and oxygenation are not well defined. The effects of dobutamine (DOBU), dopamine (DOPA), and noradrenaline (NA) on splanchnic blood flows (electromagnetic flow probes), O 2 deliveries and uptakes (catheterisation of portal and hepatic veins) were studied in nine anaesthetised (ketamine/flunitrazepam), ventilated, paralysed, and laparotomised pigs. All three catecholamines (DOPA at 15 μg·kg ‐1 · min ‐1 , DOBU at 13 μg · kg ‐1 · min ‐1 , NA at 0.4 μg · kg ‐1 · min ‐1 ) significantly ( P <0.05) increased cardiac output and systemic O 2 delivery. Only DOPA increased small intestinal and total hepatic blood flows, and O 2 deliveries, and decreased O 2 extractions. The same parameters did not change during DOBU. During NA, total hepatic blood flow and O 2 delivery decreased, and hepatic O 2 extraction increased. During all three catecholamines, small intestinal and total hepatic O 2 uptakes did not change significantly. Whereas hepatic arterial blood flow decreased during both DOPA and NE, portal venous flow increased during DOPA. These data suggest that in the experimental model used splanchnic O 2 supply and O 2 reserve capacity appear improved by DOPA, unaffected by DOBU, and impaired by NA.