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Effects of ephedrine on oxygen consumption and cardiac output
Author(s) -
RADSTROM M.,
BENGTSSON J.,
EDERBERG S.,
BENGTSSON A.,
LOSWICK A. C.,
BENGTSON J. P.
Publication year - 1995
Publication title -
acta anaesthesiologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.738
H-Index - 107
eISSN - 1399-6576
pISSN - 0001-5172
DOI - 10.1111/j.1399-6576.1995.tb04235.x
Subject(s) - medicine , ephedrine , respiratory quotient , anesthesia , heart rate , oxygen , cardiac output , cardiac index , blood pressure , respiration , excretion , bolus (digestion) , hemodynamics , chemistry , organic chemistry , anatomy
Bolus doses of ephedrine are often used by anaesthesiologists for intraoperative hypotension. This randomized single‐blind cross‐over study was designed to simultaneously evaluate circulatory, respiratory and metabolic effects of intravenously given ephedrine in 12 healthy male volunteers. Oxygen uptake and carbon dioxide excretion were measured with indirect calorimetry and non‐invasive transthoracic electrical bioimpedance was used for cardiac output measurements. The maximum effect on most variables was reached at 4‐5 min. At 5 min after the administration of ephedrine 0.1 mg per kilogram body weight, there were significant increases in cardiac index, systolic and mean arterial blood pressure, expired minute volume, oxygen uptake and carbon dioxide excretion rates. There were no significant changes in the quotient between oxygen uptake rate and cardiac index, VO 2 /CI during the 30 min study period. The O 2 saturation was not altered. The present study indicates that ephedrine increases oxygen demand and supply in a similar magnitude.